1-Chloro-5-fluoro-2-methoxy-4-nitrobenzene → 4-Chloro-2-fluoro-5-methoxybenzenesulphonyl chloride

반응식

C(C1C=CC([S:9]([Cl:12])(=[O:11])=[O:10])=CC=1OCC)#N.[Cl:16][C:17]1[CH:22]=[C:21]([F:23])[C:20]([N+]([O-])=O)=[CH:19][C:18]=1[O:27][CH3:28]>>[Cl:16][C:17]1[C:18]([O:27][CH3:28])=[CH:19][C:20]([S:9]([Cl:12])(=[O:11])=[O:10])=[C:21]([F:23])[CH:22]=1

참가 물질

반응물 2

HCID 27792951-Chloro-5-fluoro-2-methoxy-4-nitrobenzene

HCID 552808794-Cyano-3-ethoxybenzene-1-sulfonyl chloride2회

생성물 1

HCID 848060544-Chloro-2-fluoro-5-methoxybenzenesulphonyl chloride

실험 절차

The titled compound was prepared analogously to 4-cyano-3-ethoxy-benzenesulfonyl chloride (Intermediate 127c) by replacing 2-ethoxy-4-nitro-benzonitrile with 1-chloro-5-fluoro-2-methoxy-4-nitro-benzene.

출처 및 근거

ORD 기록: ord-9be9407e298b4754a924a0ed2a03cde6
출처 데이터셋: uspto-grants-2015_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09169251B2

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