A solution of 8-Bromo-1,3,7-trimethyl xanthine (315 mg, 1.15 mmol) and 3,4-dimethoxy phenylboronic acid (230 mg; 1.26 mmol) in 1,4-dioxane (5 ml) was treated tetrakis(triphenyl phosphine) palladium (0) (88 mg, 0.14 mmol) and potassium carbonate (277 mg, 2.0 mmol). The mixture was heated to 70° C. for 12 hrs under argon atmosphere. The reaction mixture was concentrated under reduced pressure. The residue was purified on a silica gel column eluting with 70% ethyl acetate in hexane to 100% ethyl acetate. The desired product was isolated as off white solid, Yield 297 mg, 78% PRO-04-46
