Nitric Acid → N-(4-fluoro-2-methyl-6-nitrophenyl)acetamide

HRID 17547

반응식

HRID 17547 반응식
[N+:1]([O-:4])(O)=[O:2].[F:5][C:6]1[CH:11]=[CH:10][C:9]([NH:12][C:13](=[O:15])[CH3:14])=[C:8]([CH3:16])[CH:7]=1>C(O)(=O)C>[F:5][C:6]1[CH:11]=[C:10]([N+:1]([O-:4])=[O:2])[C:9]([NH:12][C:13](=[O:15])[CH3:14])=[C:8]([CH3:16])[CH:7]=1

참가 물질

4

반응물 2

HCID 944Nitric AcidHCID 2737623N-(4-Fluoro-2-methylphenyl)acetamide

생성물 1

HCID 54330341N-(4-fluoro-2-methyl-6-nitrophenyl)acetamide수율 87%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

With cooling with ice, fuming nitric acid (25 ml) was dropwise added to an acetic acid (100 ml) solution of N-(4-fluoro-2-methylphenyl)acetamide (I-259) (10.0 g, 59.8 mmol), taking 50 minutes. After the addition, then restoration to room temperature and stirring for 23 hours, the reaction liquid was poured into ice. The precipitated solid was collected by filtration, washed with water, then dried to obtain the entitled compound (11.1 g, 87%) as a pale brown solid.

후처리

  1. additionAfter the addition
  2. customthe reaction liquid
  3. additionwas poured into ice
  4. filtrationThe precipitated solid was collected by filtration
  5. washwashed with water
  6. customdried

출처 및 근거

ORD 기록
ord-c0b4e5a56fc740aabdc16f007c2e158d
출처 데이터셋
uspto-grants-2010_06
특허 번호
US07737166B2

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