Formic Acid → 5-bromo-6-(trifluoromethyl)-1H-benzo[d]imidazole

HRID 1754967노트

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HRID 1754967 반응식
[Br:1][C:2]1[CH:3]=[C:4]([NH2:13])[C:5]([NH2:12])=[CH:6][C:7]=1[C:8]([F:11])([F:10])[F:9].[CH:14](O)=O>>[Br:1][C:2]1[C:7]([C:8]([F:11])([F:10])[F:9])=[CH:6][C:5]2[NH:12][CH:14]=[N:13][C:4]=2[CH:3]=1

참가 물질

3

반응물 2

HCID 284Formic AcidHCID 105389214-Bromo-5-(trifluoromethyl)benzene-1,2-diamine

생성물 1

HCID 594745905-bromo-6-(trifluoromethyl)-1H-benzo[d]imidazole

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온도
120 °C

실험 절차

4-Bromo-5-trifluoromethyl-benzene-1,2-diamine (200 mg, 0.785 mmol) was dissolved in formic acid (3 ml), and the mixture was stirred at 120° C. for six hours. The reaction solution was concentrated, and water was added to the resulting residue, followed by extraction with ethyl acetate. The organic layer was washed with water and saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 5-bromo-6-trifluoromethyl-1H-benzimidazole (201 mg) as a crude compound.

후처리

  1. concentrationThe reaction solution was concentrated
  2. additionwater was added to the resulting residue
  3. extractionfollowed by extraction with ethyl acetate
  4. washThe organic layer was washed with water and saturated brine
  5. dry with materialdried over anhydrous sodium sulfate
  6. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-52cb3350046b47b7bd05642a780922b7
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09169254B2

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