6-Fluoropyridin-2-amine → (S)-6-(2-methylpyrrolidin-1-yl)pyridin-2-amine

HRID 1755330노트

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HRID 1755330 반응식
F[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][CH:3]=1.[CH3:9][C@H:10]1[CH2:14][CH2:13][CH2:12][NH:11]1>O>[CH3:9][C@H:10]1[CH2:14][CH2:13][CH2:12][N:11]1[C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][CH:3]=1

참가 물질

4

반응물 2

HCID 27613996-Fluoropyridin-2-amineHCID 6999702(2S)-2-methylpyrrolidine

생성물 1

HCID 86674492(S)-6-(2-methylpyrrolidin-1-yl)pyridin-2-amine수율 84.6%

시약·촉매·용매 1

HCID 962Water용매

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온도
205 °C

실험 절차

A suspension of 6-fluoropyridin-2-amine (1.12 g, 10 mmol) and (S)-2-methylpyrrolidine (1.03 g, 12 mmol) in water (1 mL) was heated to 205° C. in a microwave oven for 30 minutes. The reaction mixture was purified by chromatography (silica gel, 200-300 mesh, petroleum ether:ethyl acetate=5:1) to give (S)-6-(2-methylpyrrolidin-1-yl)pyridin-2-amine (1.5 g, 83%) as a colorless oil. LC-MS: [M+H]+, 178.2, tR=1.066 min.

후처리

  1. customThe reaction mixture was purified by chromatography (silica gel, 200-300 mesh, petroleum ether:ethyl acetate=5:1)

출처 및 근거

ORD 기록
ord-d8d31159389742638eeea06f7d6d6a05
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09169259B2

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