Trifluoroacetic acid → (2S)-2-((2S)-2-(2-(5-Formylthiazol-2-ylamino)-3-methylbutanamido)propanamido)propanoic acid

HRID 1755447노트

반응식

HRID 1755447 반응식
[CH:1]([C:3]1[S:7][C:6]([NH:8][CH:9]([CH:27]([CH3:29])[CH3:28])[C:10]([NH:12][C@@H:13]([CH3:26])[C:14]([NH:16][C@@H:17]([CH3:25])[C:18]([O:20]C(C)(C)C)=[O:19])=[O:15])=[O:11])=[N:5][CH:4]=1)=[O:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH:1]([C:3]1[S:7][C:6]([NH:8][CH:9]([CH:27]([CH3:29])[CH3:28])[C:10]([NH:12][C@@H:13]([CH3:26])[C:14]([NH:16][C@@H:17]([CH3:25])[C:18]([OH:20])=[O:19])=[O:15])=[O:11])=[N:5][CH:4]=1)=[O:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acid2회HCID 89867008(2S)-tert-Butyl 2-((2S)-2-(2-(5-formylthiazol-2-ylamino)-3-methylbutanamido)propanamido)propanoate

생성물 1

HCID 89858110(2S)-2-((2S)-2-(2-(5-Formylthiazol-2-ylamino)-3-methylbutanamido)propanamido)propanoic acid수율 145.2%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

Following the procedure as described in Example 11, except using material from Example 26 (213 mg, 0.499 mmol), CH2Cl2 (75 mL) and TFA (25 mL, 324 mmol), 268.4 mg (quantitative yield) of the title compound is obtained as a white solid as a mono TFA salt. LC/MS (Condition A): ret. T=2.15 min, (M+H)+ 371.14.

출처 및 근거

ORD 기록
ord-82daa52006804221a035e4477c7d8b38
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09169295B2

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