Piperidine → HCID 89869680, 화합물

HRID 1755482노트

반응식

HRID 1755482 반응식
C1C2C(COC(=O)[NH:17][C@@H:18]([CH3:42])[C:19](=[O:41])[NH:20][C@@H:21]([CH2:33][C:34]3[CH:39]=[CH:38][C:37]([OH:40])=[CH:36][CH:35]=3)[C:22](=[O:32])[NH:23][CH2:24][C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])C3C(=CC=CC=3)C=2C=CC=1.N1CCCCC1>CN(C=O)C>[NH2:17][C@@H:18]([CH3:42])[C:19]([NH:20][C@@H:21]([CH2:33][C:34]1[CH:39]=[CH:38][C:37]([OH:40])=[CH:36][CH:35]=1)[C:22]([NH:23][CH2:24][C:25]([O:27][C:28]([CH3:29])([CH3:30])[CH3:31])=[O:26])=[O:32])=[O:41]

참가 물질

4

반응물 2

HCID 8082PiperidineHCID 89869677HCID 89869677, 화합물

생성물 1

HCID 89869680HCID 89869680, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To a solution of material from Example 99 (577 mg, 0.579 mmol) in anhydrous DMF (4 mL) is added piperidine (1 mL, 10.1 mmol). The resulting solution is stirred at room temp for 20 min, then the solvent is removed in vacuo. The resulting solid is evaporated sequentially from ethyl acetate, 1,2-dichloroethane and dichloromethane and dried under high vacuum for several hours to give the title compound as a white solid in quantitative yield that contains 1 equivalent of 1-((9H-fluoren-9-yl)methyl)piperidine as a side product. LC/MS (Condition A): ret. T=4.05 min, (M+H)+ 366.

후처리

  1. customthe solvent is removed in vacuo
  2. customThe resulting solid is evaporated sequentially from ethyl acetate, 1,2-dichloroethane and dichloromethane
  3. customdried under high vacuum for several hours

출처 및 근거

ORD 기록
ord-935231ace1cd4fc98bb0488045dfb424
출처 데이터셋
uspto-grants-2015_10
특허 번호
US09169295B2

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