참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 2,5 Dibromotoluene | HCID 12006 | — |
| 반응물 | 4-(Diphenylamino)phenylboronic Acid (contains varying amounts of Anhydride) | HCID 12166934 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 용매 | 1,4-Dioxane--water (1/1) | HCID 21886435 | — |
| 생성물 | 4'-bromo-3'-methyl-N,N-diphenyl-[1,1'-biphenyl]-4-amine | HCID 86712049 | 67% |
반응 단계
A mixture of 4-diphenylaminophenyl boronic acid (1.25 g, 4.33 mmol), 2,5-dibromotoluene (2.16 g, 8.65 mmol), Pd(PPh3)4 (0.25 g, 0.22 mmol) and K2CO3 (1.38 g, 10 mmol) in dioxane/water (50 mL/9 mL) was degassed and heated at 80° C. for 15 hours. The resulting mixture was mixed with ethyl acetate/brine. The organic phase was dried over Na2SO4, loaded on silica gel, and purified by flash column (hexanes to hexanes/dichloromethane 9:1 to 4:1). The desired fraction was collected and concentrated. After removal of solvent, a white solid (Compound 18) was obtained (1.2 g, in 67% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US09172051B2 |
|---|
| 출처 데이터셋 | uspto-grants-2015_10 |
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| ORD ID | ord-1845db619ac84613b0101efc6c84ec6b |
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| 출처 메모 | uspto-grants-2015_10 |
|---|
