Allyl bromide → N-allyl-D-alanine t-butyl ester
반응식
[C:1]([O:5][C:6](=[O:10])[C@@H:7]([CH3:9])[NH2:8])([CH3:4])([CH3:3])[CH3:2].[CH2:11](Br)[CH:12]=[CH2:13].C(N(CC)CC)C>C1(C)C=CC=CC=1>[C:1]([O:5][C:6](=[O:10])[C@@H:7]([CH3:9])[NH:8][CH2:13][CH:12]=[CH2:11])([CH3:4])([CH3:3])[CH3:2]참가 물질
5
실험 절차
D-Alanine t-butylester (68) is treated with one equivalent allyl bromide and one equivalent of triethylamine in toluene under reflux. The solvent is evaporated and the product is purified by flash chromatography on silica gel to give (69).
후처리
- temperatureunder reflux
- customThe solvent is evaporated
- customthe product is purified by flash chromatography on silica gel
출처 및 근거
- ORD 기록
- ord-48efffad11d94dafa55ea06d132ab9b7
- 출처 데이터셋
- uspto-grants-1995_08
- 특허 번호
- US05438118
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