Hydroxylamine → HCID 178523962, 화합물
반응식
C([O:4][CH2:5][C:6]1[N:19]=[C:9]2[N:10]=[C:11]([C:15](OC)=[O:16])[CH:12]=[C:13]([SH:14])[N:8]2[N:7]=1)(=O)C.[NH2:20][OH:21]>CO>[OH:21][NH:20][C:15]([C:11]1[CH:12]=[C:13]([SH:14])[N:8]2[N:7]=[C:6]([CH2:5][OH:4])[N:19]=[C:9]2[N:10]=1)=[O:16]참가 물질
4
실험 절차
Methyl 2-(acetoxymethyl)-7-mercapto-s-triazolo[1,5-a]pyrimidine-5-carboxylate (80 mg) (0.28 mmol) are dissolved in 3 ml of absolute methanol. 188 mg (5.7 mmol) of hydroxylamine are added within 4 days while stirring. The product is precipitated (pH 6) with 3N aqueous hydrochloric acid, filtered off under suction and washed with methanol. After crystallization from methanol there are obtained 50 mg of N-hydroxy-2-(hydroxymethyl)-7-mercapto-s-triazolo[1,5-a]pyrimidine-5-carboxamide as a yellow powder.
후처리
- customThe product is precipitated (pH 6) with 3N aqueous hydrochloric acid
- filtrationfiltered off under suction
- washwashed with methanol
- customAfter crystallization from methanol
출처 및 근거
- ORD 기록
- ord-404092c8a41343869b131343689daef4
- 출처 데이터셋
- uspto-grants-1995_08
- 특허 번호
- US05438052
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