Tetramethyl pyrazine-2,3,5,6-tetracarboxylate → 2,3,5,6-Tetramethoxycarbonylpiperazine

HRID 1755963노트

반응식

HRID 1755963 반응식
[CH3:1][O:2][C:3]([C:5]1[N:10]=[C:9]([C:11]([O:13][CH3:14])=[O:12])[C:8]([C:15]([O:17][CH3:18])=[O:16])=[N:7][C:6]=1[C:19]([O:21][CH3:22])=[O:20])=[O:4]>C(O)C.[Pd]>[CH3:1][O:2][C:3]([CH:5]1[CH:6]([C:19]([O:21][CH3:22])=[O:20])[NH:7][CH:8]([C:15]([O:17][CH3:18])=[O:16])[CH:9]([C:11]([O:13][CH3:14])=[O:12])[NH:10]1)=[O:4]

참가 물질

4

반응물 1

HCID 291621Tetramethyl pyrazine-2,3,5,6-tetracarboxylate

생성물 1

HCID 233626442,3,5,6-Tetramethoxycarbonylpiperazine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

A solution of tetrakis-methoxycarbonylpyrazine (5.3 g, 16.9 mmol) (prepared in accordance with J. Org. Chem. 37 (19), p2963 (1972)) in 800 ml of dry ethanol, was hydrogenated at 50 bar in the presence of 10 g 5% palladium on charcoal at 80° C. for 16 hours. After cooling, the solution was filtered and evaporated to give slightly yellow crystals. Yield: 4.8 g (90%) , mp. 162°-163° C. (Lit. 162°-163° C.). NMR confirmed the structure.

후처리

  1. temperatureAfter cooling
  2. filtrationthe solution was filtered
  3. customevaporated
  4. customto give slightly yellow crystals
  5. customYield: 4.8 g (90%) , mp. 162°-163° C. (Lit. 162°-163° C.)

출처 및 근거

ORD 기록
ord-99063e4947ee44f7af615ba019cf99fc
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05439668

반응 노트

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