2-Chloroacetophenone → 3Chloro-2-methyl-7-phenacylpyrrolo-[2,3-b]pyridinehydrochloride
반응식
[Cl:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][C:3]=1[CH3:11].Cl[CH2:13][C:14]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:15]>CC#N>[ClH:1].[Cl:1][C:2]1[C:10]2[C:5]([N:6]([CH2:13][C:14]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)=[O:15])[CH:7]=[CH:8][CH:9]=2)=[N:4][C:3]=1[CH3:11]참가 물질
4
실험 절차
A solution of 200 mg (1.2 mmol) of 3-chloro-2-methyl pyrrolo-[2,3-b]pyridine and 204 mg (1,3 mmol) of 2-chloroacetophenon in 10 ml of CH3CN was refluxed for 48 h. The reaction mixture was cooled to room temperature and stirred for one hour. The precipitate was filtered off to give 260 mg (67%) of 3chloro-2-methyl-7-phenacylpyrrolo-[2,3-b]pyridinehydrochloride.
후처리
- filtrationThe precipitate was filtered off
출처 및 근거
- ORD 기록
- ord-e4bc02c4e71b48c0b008201024215e37
- 출처 데이터셋
- uspto-grants-1995_08
- 특허 번호
- US05439917
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