2-Chloro-4'-fluoroacetophenone → HCID 23207150, 화합물

HRID 1756078노트

반응식

HRID 1756078 반응식
[C:1]([CH2:3][C:4]1[C:12]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[NH:6][C:5]=1[CH3:13])#[N:2].[F:14][C:15]1[CH:24]=[CH:23][C:18]([C:19](=[O:22])[CH2:20][Cl:21])=[CH:17][CH:16]=1>C(#N)C>[ClH:21].[C:1]([CH2:3][C:4]1[C:12]2[C:7]([N:8]([CH2:20][C:19]([C:18]3[CH:23]=[CH:24][C:15]([F:14])=[CH:16][CH:17]=3)=[O:22])[CH:9]=[CH:10][CH:11]=2)=[N:6][C:5]=1[CH3:13])#[N:2]

참가 물질

4

반응물 2

HCID 1202482-Chloro-4'-fluoroacetophenoneHCID 19916764(2-Methyl-1H-pyrrolo[2,3-b]pyridin-3-yl)acetonitrile

생성물 1

HCID 23207150HCID 23207150, 화합물수율 55%

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

A solution of 7 5 mg (0.44 mmol) of 3-cyanomethyl-2-methyl-pyrrolo [2,3 -b]pyridine and 99 mg(0.57 mmol) of 4-fluorophenacyl chloride in 1 ml acetonitrile was refluxed for 48 h. The solvent was evaporated and the residue was treated with 0.4 ml acetonitrile. After filtration the solid was treated with 0,3 ml methanol and 0,4 ml acetonitrile to give 75 mg (55% ) of the title compound.

후처리

  1. customThe solvent was evaporated
  2. additionthe residue was treated with 0.4 ml acetonitrile
  3. filtrationAfter filtration the solid
  4. additionwas treated with 0,3 ml methanol and 0,4 ml acetonitrile

출처 및 근거

ORD 기록
ord-5bc533e53c32447ba8b1bceb44421817
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05439917

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