Sulfuryl chloride → 2-chloro-3-methyl-1H-pyrrolo[2,3-b]pyridine
반응식
[CH3:1][C:2]1[C:10]2[C:5](=[N:6][CH:7]=[CH:8][CH:9]=2)[NH:4][CH:3]=1.S(Cl)([Cl:14])(=O)=O>C(O)(=O)C>[Cl:14][C:3]1[NH:4][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:10]2[C:2]=1[CH3:1]참가 물질
4
실험 절차
3-methylpyrrolo[2,3-b]pyridine (0,5 g 0.0038 mol) was treated in 2 ml acetic acid with an equimolecular amount of sulfuryl chloride at 0° C. for 5 min. The mixture was allowed to warm to room temperature and was stirred for 5 min. After evaporation the residue was dissolved in methylene chloride and was treated with bicarbonate. The organic layer was separated, dried and removed under reduced pressure. Chromatography on silica gel eluting with ethyl acetate gave the desired product. (0,18 g 29%).
후처리
- customAfter evaporation the residue
- dissolutionwas dissolved in methylene chloride
- additionwas treated with bicarbonate
- customThe organic layer was separated
- customdried
- customremoved under reduced pressure
출처 및 근거
- ORD 기록
- ord-51ced4447db94485886c5ff981b71509
- 출처 데이터셋
- uspto-grants-1995_08
- 특허 번호
- US05439917
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