Sulfuryl chloride → 1H-Pyrrolo[2,3-b]pyridine-3-acetonitrile, 2-chloro-
반응식
[C:1]([CH2:3][C:4]1[C:12]2[C:7](=[N:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1)#[N:2].S(Cl)([Cl:16])(=O)=O>C(O)(=O)C>[Cl:16][C:5]1[NH:6][C:7]2=[N:8][CH:9]=[CH:10][CH:11]=[C:12]2[C:4]=1[CH2:3][C:1]#[N:2]참가 물질
4
실험 절차
3-cyanomethylpyrrolo[2,3-b]pyridine (1,55 g, 0.098 mol) was treated in 5 ml acetic acid with an equimolecular amount of sulfurylchloride at 0° C. for 5 min. The mixture was allowed to warm to room temperature and was stirred 5 min. After evaporation the residue was dissolved in methylen chloride and was treated with bicarbonate. The organic layer was separated, dried over Na2SO4 and the solvent was removed under reduced pressure. Chromatography on silica gel eluting with ethyl acetate gave the desired product. (0,4 g 21%).
후처리
- customAfter evaporation the residue
- dissolutionwas dissolved in methylen chloride
- additionwas treated with bicarbonate
- customThe organic layer was separated
- dry with materialdried over Na2SO4
- customthe solvent was removed under reduced pressure
출처 및 근거
- ORD 기록
- ord-35ec616ca9f1410dbe3bae3a04a93e87
- 출처 데이터셋
- uspto-grants-1995_08
- 특허 번호
- US05439917
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