2,5-Dimethylpyrazine → 2,5-Divinylpyrazine

HRID 1756146

반응식

HRID 1756146 반응식
CC1C=NC(C)=CN=1.CN([CH2:12][CH2:13][C:14]1[CH:19]=[N:18][C:17]([CH2:20][CH2:21]N(C)C)=[CH:16][N:15]=1)C>>[CH:13]([C:14]1[CH:19]=[N:18][C:17]([CH:20]=[CH2:21])=[CH:16][N:15]=1)=[CH2:12]

참가 물질

3

반응물 2

HCID 312522,5-DimethylpyrazineHCID 541818482,5-bis(N,N-dimethylaminoethyl)pyrazine

생성물 1

HCID 193495062,5-Divinylpyrazine수율 47%

실험 절차

The procedure of Example 1 was followed using 2,5-dimethylpyrazine as the starting material. The intermediate, 2,5-bis(N,N-dimethylaminoethyl)pyrazine, was prepared at a yield of 47% (118°-130° C./1.2 mm Hg). The product 2,5-divinylpyrazine was collected at 46°-50° C./1.2 mm Hg (36%, nD =1.595). It was found to be slightly soluble in water. 1H NMR (CDCl3) δ 5.57 (2H, dd, J=9.0, 1.2 Hz), 6.31 (2H, dd, J=17.7, 1.2 Hz), 6.80 (2H, dd, J=17.7, 9.0 Hz), 8.51 (2H, s); 13C NMR (CDCl3) δ 120.18, 133.27, 142.31, 149.38.

후처리

  1. customThe product 2,5-divinylpyrazine was collected at 46°-50° C./1.2 mm Hg (36%, nD =1.595)

출처 및 근거

ORD 기록
ord-4af259165735477fa8758f9830fd3531
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05439950

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