Thionyl Chloride → 5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetyl chloride

HRID 1756417

반응식

HRID 1756417 반응식
[CH3:1][C:2]1([CH3:18])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([CH2:14][C:15](O)=[O:16])[CH:5]=[CH:4][C:3]1=2.S(Cl)([Cl:21])=O>>[CH3:1][C:2]1([CH3:18])[CH2:11][CH2:10][C:9]([CH3:13])([CH3:12])[C:8]2[CH:7]=[C:6]([CH2:14][C:15]([Cl:21])=[O:16])[CH:5]=[CH:4][C:3]1=2

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 181779322-(5,5,8,8-Tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)acetic acid

생성물 1

HCID 214744835,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetyl chloride

실험 절차

6.6 g (26.8 mmol) of 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthylacetic acid and 20 ml of thionyl chloride are heated to reflux until gaseous evolution has ceased. The mixture is evaporated to dryness and 7.1 g (100%) of the crude acid chloride are obtained, which product is used for the next step of the synthesis without further treatment.

후처리

  1. temperatureto reflux until gaseous evolution
  2. customThe mixture is evaporated to dryness and 7.1 g (100%) of the crude acid chloride
  3. customare obtained
  4. customwhich product is used for the next step of the synthesis without further treatment

출처 및 근거

ORD 기록
ord-1e13343e001945cba027dd7b756cd264
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05439925

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