Water → N-allyl-5-azaisatin

HRID 1756560노트

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HRID 1756560 반응식
[CH2:1]([N:4]1[C:10](=O)[O:9][C:7](=[O:8])[C:6]2=[CH:12][N:13]=[CH:14][CH:15]=[C:5]12)[CH:2]=[CH2:3].[C-]#N.[K+].O>CN(C=O)C>[CH2:1]([N:4]1[C:5]2[C:6](=[CH:12][N:13]=[CH:14][CH:15]=2)[C:7](=[O:8])[C:10]1=[O:9])[CH:2]=[CH2:3]

참가 물질

5

반응물 3

HCID 962WaterHCID 9032Potassium CyanideHCID 86595201N-allyl-5-azaisatoic anhydride

생성물 1

HCID 19390720N-allyl-5-azaisatin

시약·촉매·용매 1

HCID 6228Dimethylformamide용매2회

반응 조건

온도
100 °C

실험 절차

A solution of N-allyl-5-azaisatoic anhydride (20 mmol) in DMF is added dropwise to a suspension of pulverized potassium cyanide (21 mmol) in DMF at 100° C. The reaction mixture is stirred at 100° C. for an additional 5 min after which time the mixture is poured into cold water and extracted with ether. The organic layer is dried (Na2SO4), filtered and the solvent is removed. Stirring the resulting residue in 2N hydrochloric acid overnight and adjusting the pH to 7 gives, upon filtration, N-allyl-5-azaisatin.

후처리

  1. extractionextracted with ether
  2. dry with materialThe organic layer is dried (Na2SO4)
  3. filtrationfiltered
  4. customthe solvent is removed
  5. stirringStirring the resulting residue in 2N hydrochloric acid overnight

출처 및 근거

ORD 기록
ord-e134912baed44531ba06493a8a2a91dc
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05441955

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