N-allyl-5-azaisatin → 1H-Pyrrolo[3,2-c]pyridine-2,3-dione

HRID 1756561노트

반응식

HRID 1756561 반응식
C([N:4]1[C:14]2[C:9](=[CH:10][N:11]=[CH:12][CH:13]=2)[C:7](=[O:8])[C:5]1=[O:6])C=C>C1(C)C=CC=CC=1>[NH:4]1[C:14]2[C:9](=[CH:10][N:11]=[CH:12][CH:13]=2)[C:7](=[O:8])[C:5]1=[O:6]

참가 물질

3

반응물 1

HCID 19390720N-allyl-5-azaisatin

생성물 1

HCID 107019651H-Pyrrolo[3,2-c]pyridine-2,3-dione

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

A solution of N-allyl-5-azaisatin (5.3 mmol), (Ph3P)3RhCl (0.5 mmol) in aqueous toluene is stirred under a nitrogen atmosphere at room temperature overnight. The organic layer is dried (MgSO4) and the solvent is evaporated. The residue is stirred in 1N HCl/MeOH for 15 min after which time the methanol is evaporated and the pH of the water is adjusted to 7. A precipitate is formed and purified by silica gel chromatography (1% MeOH:CHCl3) to obtain the title compound.

후처리

  1. dry with materialThe organic layer is dried (MgSO4)
  2. customthe solvent is evaporated
  3. customis evaporated
  4. customA precipitate is formed
  5. custompurified by silica gel chromatography (1% MeOH:CHCl3)

출처 및 근거

ORD 기록
ord-13e4f4d258794ec5a2973b4328ee72fb
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05441955

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