5-Bromoisatin → 8-Bromoindolo[2,1-b]quinazoline-6,12-dione

반응식

Cl[C:2]1[CH:13]=[C:6]2[C:7](OC(=O)[NH:11][C:5]2=[CH:4][CH:3]=1)=[O:8].[Br:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[NH:20][C:19](=O)[C:18]2=[O:25].FC1C=C2C(=CC=1)NC(=O)C2=O>>[Br:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][CH:23]=1)[N:20]1[C:19](=[N:11][C:5]3[C:6]([C:7]1=[O:8])=[CH:13][CH:2]=[CH:3][CH:4]=3)[C:18]2=[O:25]

참가 물질

반응물 3

HCID 68895-Bromoisatin

HCID 784805-Chloroisatoic anhydride

HCID 2365665-Fluoroisatin

생성물 1

HCID 4785728-Bromoindolo[2,1-b]quinazoline-6,12-dione수율 9%

실험 절차

Using the procedure in Example 12 and substituting isatoic anhydride for 5-chloroisatoic anhydride and 5-bromoisatin for 5-fluoroisatin gave the title compound in 9% yield: mp 288°-290.2° C.; 1H NMR (300 MHz, CDCl3) δ 8.56 (d, 1H) 8.44 (d, 1H) 8.06 (s, 1H) 8.04 (s, 1H) 7.82-7.96 (m, 2H) 7.66-7.76 (m, 1H); MS (M+H)+ 328.

출처 및 근거

ORD 기록: ord-faa0b8283f7c4b31b405c8958c5f3fea
출처 데이터셋: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05441955

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