Isatin → 2-Aminonicotinic acid

반응식

N1C2C(=CC=CC=2)C(=O)C1=O.[NH2:12][C:13]1[N:21]=[CH:20][C:19](Cl)=[CH:18][C:14]=1[C:15]([OH:17])=[O:16].N[C@H](C(O)=O)CC>>[NH2:12][C:13]1[N:21]=[CH:20][CH:19]=[CH:18][C:14]=1[C:15]([OH:17])=[O:16]

참가 물질

반응물 3

HCID 7054Isatin

HCID 80283(-)-2-Aminobutyric acid

HCID 193907282-Amino-5-chloropyridine-3-carboxylic acid

생성물 1

HCID 729302-Aminonicotinic acid

실험 절차

Using the procedure in Example 56 and substituting 5-fluoroisatin for isatin and 2-amino-5-chloronicotinic acid (Abu El-Haj et al., U.S. Pat. No. 3,917,624, 1975) for 2-aminonicotinic acid gives the title compound.

출처 및 근거

ORD 기록: ord-3146c6ebbfba4bd79266e556fded5967
출처 데이터셋: uspto-grants-1995_08
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05441955

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