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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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2-{4-[4-(4,5-Dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-benzyloxypyrimidine → 2-{4-[4-(4,5-Dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-hydroxypyrimidine

HRID 1757062
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인쇄 미리보기

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HRID 1757062 반응식
[Cl:1][C:2]1[N:3]=[C:4]([CH3:32])[N:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:17][CH2:16][N:15]([C:18]3[N:23]=[CH:22][C:21]([O:24]CC4C=CC=CC=4)=[CH:20][N:19]=3)[CH2:14][CH2:13]2)[C:6]=1[Cl:7]>[Pd].CO>[Cl:1][C:2]1[N:3]=[C:4]([CH3:32])[N:5]([CH2:8][CH2:9][CH2:10][CH2:11][N:12]2[CH2:13][CH2:14][N:15]([C:18]3[N:23]=[CH:22][C:21]([OH:24])=[CH:20][N:19]=3)[CH2:16][CH2:17]2)[C:6]=1[Cl:7]
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 1

HCID 193897772-{4-[4-(4,5-Dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-benzyloxypyrimidine

생성물 1

HCID 193897762-{4-[4-(4,5-Dichloro-2-methylimidazol-1-yl)butyl]-1-piperazinyl}-5-hydroxypyrimidine수율 59.1%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

반응 조건

온도
24 °C

실험 절차

A mixture of 2.90 g (6.10 mmol) of 2-{4-[4-(4,5-dichloro-2-methylimidazol-1-yl )butyl]-1-piperazinyl}-5-benzyloxypyrimidine and 0.30 g of 10% palladium on carbon in 50 ml of methanol is stirred for 12 hours under a hydrogen atmosphere at room temperature (24° C.) and at a pressure of 0.28 MPa. After filtration, washing with methanol and evaporation to dryness, the product is chromatographed on silica gel, yielding 1.39 g (59%) of 2-{4-[4-(4,5-dichloro-2-methylimidazol -1-yl)butyl]-1-piperazinyl}-5-hydroxypyrimidine with a melting point of 154°-6° C.

후처리

  1. filtrationAfter filtration
  2. washwashing with methanol and evaporation to dryness
  3. customthe product is chromatographed on silica gel

출처 및 근거

ORD 기록
ord-4c20446dcdc4416489fc29654b713d14
출처 데이터셋
uspto-grants-1995_08
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05444059

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