Ethyl benzoylacetate → ethyl 2-bromo-3-oxo-3-phenylpropanoate

HRID 1757126노트

반응식

HRID 1757126 반응식
[CH3:1][CH2:2][O:3][C:4]([CH2:6][C:7]([C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1)=[O:8])=[O:5].[Br:15]Br>C(Cl)(Cl)(Cl)Cl>[C:7]([CH:6]([Br:15])[C:4]([O:3][CH2:2][CH3:1])=[O:5])(=[O:8])[C:9]1[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=1

참가 물질

4

반응물 2

HCID 7170Ethyl benzoylacetateHCID 24408Bromine

생성물 1

HCID 237819ethyl 2-bromo-3-oxo-3-phenylpropanoate

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

반응 조건

온도
60 °C

실험 절차

25 ml (0.144 mol) of ethyl benzoyl acetate are dissolved in 50 ml of CCl4, 8.5 ml of bromine are added dropwise at 5° C. and the brown solution is stirred at 5° C. for 1 h, at room temperature for 3 h and at 60° C. for 2 h. It is concentrated to dryness, the residue is taken up in EA, the EA solution is washed with 10% strength Na2SO3 solution and satd. NaCl solution, dried over MgSO4 and concentrated, and the residue is dried in a high vacuum. 38 g of the title compound result as a red oil.

후처리

  1. concentrationIt is concentrated to dryness
  2. washthe EA solution is washed with 10% strength Na2SO3 solution
  3. dry with materialNaCl solution, dried over MgSO4
  4. concentrationconcentrated
  5. customthe residue is dried in a high vacuum

출처 및 근거

ORD 기록
ord-7962c21bbe71411e949aeb54f24edc13
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05444068

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