1-(2-chlorophenyl)methyl-5-carboxymethyl-2-propylthio-1H-imidazole → methyl 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetate hydro-chloride

HRID 1757191노트

반응식

HRID 1757191 반응식
[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][N:9]1[C:13]([CH:14](C(OCC)=O)[C:15]([O:17][CH2:18]C)=[O:16])=[CH:12][N:11]=[C:10]1[S:25][CH2:26][CH2:27][CH3:28].ClC1C=CC=CC=1CN1C(CC(O)=O)=CN=C1SCCC>CO.Cl>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][N:9]1[C:13]([CH2:14][C:15]([O:17][CH3:18])=[O:16])=[CH:12][N:11]=[C:10]1[S:25][CH2:26][CH2:27][CH3:28]

참가 물질

4

반응물 2

HCID 193515541-(2-chlorophenyl)methyl-5-carboxymethyl-2-propylthio-1H-imidazoleHCID 54435009Diethyl [1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]malonate

생성물 1

HCID 22400438methyl 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetate hydro-chloride

시약·촉매·용매 1

HCID 21893726Hydrochloride methanol용매

실험 절차

Diethyl [1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]malonate was converted to 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5-yl]acetic acid by the method described in Example 15. The methyl ester was prepared in methanol/hydrochloric acid to give methyl 2-[1-{(2-chlorophenyl)methyl}-2-propylthio-1H-imidazol-5yl]acetate hydro- chloride; mp 158°-159° C.

출처 및 근거

ORD 기록
ord-ee14ef3fb94f481ea8dd4eb433e44a87
출처 데이터셋
uspto-grants-1995_08
특허 번호
US05444080

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