4-Nitropyridine-2-carboxylic acid 1-oxide → 4-Aminopicolinic acid
반응식
[C:1]([C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[CH:6][N+:5]=1[O-])([OH:3])=[O:2]>C(O)(=O)C.[Pd]>[C:1]([C:4]1[CH:9]=[C:8]([NH2:10])[CH:7]=[CH:6][N:5]=1)([OH:3])=[O:2]참가 물질
4
실험 절차
A solution of 2-carboxy-4-nitropyridine N-oxide (0.5 g, 27 mmol) (E. Prafft et al., J. Prakt. Chem. 1961, 13, 58) in acetic acid (20 ml) was hydrogenated under pressure (70 psi) in the presence of Pd/C. (10%) (0.25 g) at ambient temperature for 2 hours. The catalyst was removed by filtration, and the filtrate evaporated to give 2-carboxy-4-aminopyridine as an off-white solid which was dried in a dessicator (300 mg, 80%).
후처리
- customThe catalyst was removed by filtration
- customthe filtrate evaporated
출처 및 근거
- ORD 기록
- ord-23239d1e19a64d37a243bf24ea2648d3
- 출처 데이터셋
- uspto-grants-1995_08
- 특허 번호
- US05444057
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