Benzyl Bromide → 3-Benzyloxy-4-(1-adamantyl)benzoic acid
반응식
C(Br)C1C=CC=CC=1.[CH2:9]([O:16][C:17]1[CH:18]=[C:19]([CH:24]=[CH:25][C:26]=1[C:27]12[CH2:36][CH:31]3[CH2:32][CH:33]([CH2:35][CH:29]([CH2:30]3)[CH2:28]1)[CH2:34]2)[C:20]([O:22]C)=[O:21])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>>[CH2:9]([O:16][C:17]1[CH:18]=[C:19]([CH:24]=[CH:25][C:26]=1[C:27]12[CH2:36][CH:31]3[CH2:32][CH:33]([CH2:35][CH:29]([CH2:30]3)[CH2:28]1)[CH2:34]2)[C:20]([OH:22])=[O:21])[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1참가 물질
3
실험 절차
18 g (63 mM) of the ester obtained in Example 9(a) are treated with benzyl bromide under the conditions described in Example 5(a) to lead, after the same treatment, to 17.5 g (74%) of methyl 3-benzyloxy-4-(1-adamantyl)benzoate. The derivative obtained is then saponified under the conditions described in Example 7(b) to lead, after the same treatment, to 13.6 g (96.6%) of the expected derivative, of melting point 240° C.
후처리
- customThe derivative obtained
출처 및 근거
- ORD 기록
- ord-cdab5e5c805e496ca49a6b779eea4dea