참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chloride | HCID 312 | — |
| 반응물 | Oxalyl chloride | HCID 65578 | — |
| 반응물 | 1,3-Diphenyl-2-propyn-1-one | HCID 97637 | — |
| 반응물 | 1,3-Diphenyl-2-propyn-1-ol | HCID 296659 | — |
| 반응물 | Cornforth reagent | HCID 2724130 | — |
| 반응물 | Barium manganate | HCID 3084030 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 1-Phenyl-3-[3-(4-(dimethylamino)benzyloxy)phenyl]-2-propyne-1-one | HCID 19388218 | — |
반응 단계
In step b, the appropriate α-[(phenyl)ethynyl]-benzenemethanol compound of structure 6 can be oxidized to the corresponding 1-phenyl-3-phenyl-2-propyne-1-one compound of structure 5 by techniques and procedures well known and appreciated by one of ordinary skill in the art. For example, the appropriate α-[(phenyl)ethynyl]-benzenemethanol compound of structure 6 can be oxidized to the corresponding 1-phenyl-3-phenyl-2-propyne-1-one compound of structure 5 by means of either a Swern oxidation (dimethylsulfoxide, oxalyl chloride, and triethylamine), by means of pyridinium dichromate oxidation in a suitable aprotic solvent, such as methylene chloride or by means of barium manganate oxidation in a suitable aprotic solvent, such asmethylene chloride.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US05446068 |
|---|
| 출처 데이터셋 | uspto-grants-1995_08 |
|---|
| ORD ID | ord-33804668c08843c799ea85a43fce2d24 |
|---|
| 출처 메모 | uspto-grants-1995_08 |
|---|
