Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
tert-Butyl acetate → Glycine ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | tert-Butyl acetate | HCID 10908 | — |
| 반응물 | 1H-Pyrrole-2-carboxylic acid, 3,5-dimethyl-, ethyl ester | HCID 137477 | — |
| 반응물 | Ethyl 2-amino-3-oxobutanoate | HCID 13282896 | — |
| 생성물 | Glycine ethyl ester | HCID 12176 | — |
| 생성물 | 2-Acetylcyclopentanone | HCID 98471 | — |
| 생성물 | ethyl 4-(tert-butyl)-3,5-dimethyl-1H-pyrrole-2-carboxylate | HCID 12039805 | — |
반응 단계
A Knorr cyclization between ethyl a--aminoacetoacetate (prepared in situ) and a 3-alkyl-2,4-pentandione was selected for the preparation of ethyl alkylpyrrole-2 carboxylate derivatives 4b-f, i. Ethyl 3,5-dimethyl-4-tertbutylpyrrole-2-carboxylate 4g was prepared from ethyl 3,5-dimethylpyrrole-2-carboxylate 4a in an alkylation with tert-butyl acetate. In a modification of a Knoevenagel condensation of ethyl N-(3-oxo-1-alkenyl)aminoacetates to ethylpyrrole-2-carboxylates ethyl 3-methyl-2,4,-5,6-tetrahydrocyclopenta[c]pyrrolecarboxylate 4j was obtained by a base catalyzed cyclization of an unisolated enamine 13 (Table IV), in turn obtained from a condensation between glycine ethyl ester and α-acetylcyclopentanone.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05446157 |
| 출처 데이터셋 | uspto-grants-1995_08 |
| ORD ID | ord-fc9ac76aa0df4504b6c3d75b9cf9fc8a |
| 출처 메모 | uspto-grants-1995_08 |