Methylamine → 6-amino-4-methyl-beta-carbolin-3-carboxylic acid N-methylamide

HRID 1757981노트

반응식

HRID 1757981 반응식
C(O[C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[CH:15][C:14]([NH2:20])=[CH:13][CH:12]=3)=[O:5])C.[CH3:21][NH2:22]>C(O)CO>[CH3:21][NH:22][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[CH:15][C:14]([NH2:20])=[CH:13][CH:12]=3)=[O:5]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 130373386-Amino-4-methyl-beta-carboline-3-carboxylic-acid-ethylester

생성물 1

HCID 130373546-amino-4-methyl-beta-carbolin-3-carboxylic acid N-methylamide

시약·촉매·용매 1

HCID 174Ethylene Glycol용매

실험 절차

1.81 g of 6-amino-4-methyl-β-carbolin-3-carboxylic acid ethyl ester is suspended in 15 ml of ethylene glycol and, while cooling with ice, methylamine is introduced until saturation point is reached. The mixture is then stirred at room temperature for 16 hours, stirred into 100 ml of ice water and the product is filtered off, dried and recrystallized from ethanol-chloroform. 1.42 g of 6-amino-4-methyl-β-carbolin-3-carboxylic acid N-methylamide of melting point 281°-285° C. is obtained.

후처리

  1. additionis introduced until saturation point
  2. filtrationthe product is filtered off
  3. customdried
  4. customrecrystallized from ethanol-chloroform

출처 및 근거

ORD 기록
ord-2369231a889d4ea7a28890ce88c5339e
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04371536

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