HCID 13102700, 화합물 → 3-Pyridinamine, 6-(3,4-dichlorophenoxy)-

HRID 1758002노트

반응식

HRID 1758002 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[Cl:18])[O:5][C:6]1[CH:11]=[CH:10][C:9]([N+:12]([O-])=O)=[CH:8][N:7]=1>C(O)C.[Pd]>[Cl:1][C:2]1[CH:3]=[C:4]([CH:15]=[CH:16][C:17]=1[Cl:18])[O:5][C:6]1[CH:11]=[CH:10][C:9]([NH2:12])=[CH:8][N:7]=1

참가 물질

4

반응물 1

HCID 13102700HCID 13102700, 화합물

생성물 1

HCID 5148873-Pyridinamine, 6-(3,4-dichlorophenoxy)-

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

The 2-(3,4-dichlorophenoxy)-5-nitropyridine described above was divided into 4 portions of 23.7 g each, and each portion was then hydrogenated in absolute ethanol employing a palladium catalyst as well known in the art. After removal of the catalyst, the ethanol filtrates were combined and evaporated to dryness. The residue which remained was diluted with isopropyl alcohol and hexane and then chilled. The resulting solid was collected by filtration and vacuum dried to give 70.8 g of 2-(3,4-dichlorophenoxy)-5-pyridinamine as a rose colored powder, m.p. 78°-79.3° C.

후처리

  1. customAfter removal of the catalyst
  2. customevaporated to dryness
  3. additionThe residue which remained was diluted with isopropyl alcohol and hexane
  4. temperaturechilled
  5. filtrationThe resulting solid was collected by filtration and vacuum
  6. customdried

출처 및 근거

ORD 기록
ord-c413b7171c6c49f4bc18813bf7d962e8
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04371537

반응 노트

불러오는 중…