Dimethylformamide → Methyl 4-phenylthiazolylcyanoacetate

HRID 1758126노트

반응식

HRID 1758126 반응식
[CH2:1]([S:10][C:11]#[N:12])[C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1)=O.CN(C=O)C.C(N(CC)CC)C.[C:25]([CH2:27][C:28]([O:30][CH3:31])=[O:29])#[N:26]>C(O)(=O)C.O>[C:4]1([C:2]2[N:12]=[C:11]([CH:27]([C:25]#[N:26])[C:28]([O:30][CH3:31])=[O:29])[S:10][CH:1]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

7

반응물 4

HCID 6228DimethylformamideHCID 7747Methyl cyanoacetateHCID 8471TriethylamineHCID 219693Phenacyl thiocyanate

생성물 1

HCID 20510873Methyl 4-phenylthiazolylcyanoacetate

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 962Water용매

실험 절차

90 parts of phenacyl thiocyanate are introduced into a mixture of 150 parts of DMF, 150 parts of triethylamine and 50 parts of methyl cyanoacetate. The mixture is then stirred for 4 hours at room temperature, after which it is introduced into water and the batch is acidified with acetic acid. The product which precipitates is filtered off and dried in an oven.

후처리

  1. customThe product which precipitates
  2. filtrationis filtered off
  3. customdried in an oven

출처 및 근거

ORD 기록
ord-3f94c4b018504dd88e8ccd7a2d6cdbc3
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04371734

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