Thionyl Chloride → alpha-Chloro-5-methyl-2-nitrotoluene

HRID 1758232노트

반응식

HRID 1758232 반응식
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[CH2:7]O.S(Cl)([Cl:15])=O>C1C=CC=CC=1>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([N+:10]([O-:12])=[O:11])=[C:6]([CH:9]=1)[CH2:7][Cl:15]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 568847(5-Methyl-2-nitrophenyl)methanol

생성물 1

HCID 2724031alpha-Chloro-5-methyl-2-nitrotoluene

시약·촉매·용매 1

HCID 241Benzene용매

실험 절차

The above reaction product obtained in step (a) is mixed with 600 ml of benzene and 60 ml of thionyl chloride, and left to stand for 18 hours at room temperature. The reaction solution is concentrated and subsequently partitioned between benzene and ice-water. After the organic phase is washed, dried and evaporated, the heading compound remains as an orange, semi-crystalline crude product, which is used in step (c) without further purification.

후처리

  1. waitleft
  2. concentrationThe reaction solution is concentrated
  3. customsubsequently partitioned between benzene and ice-water
  4. washAfter the organic phase is washed
  5. customdried
  6. customevaporated
  7. customis used in step (c) without further purification

출처 및 근거

ORD 기록
ord-dafb066447b244b1a73620f05b30c1e3
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04372956

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