Ethylene Glycol → HCID 54259475, 화합물

HRID 1758263노트

반응식

HRID 1758263 반응식
[CH:1]([CH:4]([C:7]1[CH:15]=[CH:14][C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=1)[C:5]#N)([CH3:3])[CH3:2].[OH-:16].[K+].C(O)C[OH:20]>O>[CH:1]([CH:4]([C:7]1[CH:15]=[CH:14][C:10]2[CH:11]=[CH:12][O:13][C:9]=2[CH:8]=1)[C:5]([OH:20])=[O:16])([CH3:3])[CH3:2]

참가 물질

5

반응물 3

HCID 174Ethylene GlycolHCID 14797Potassium HydroxideHCID 54066355HCID 54066355, 화합물

생성물 1

HCID 54259475HCID 54259475, 화합물수율 50.8%

시약·촉매·용매 1

HCID 962Water용매2회

반응 조건

온도
140 °C

실험 절차

A mixture of α-isopropylbenzofuran-6-acetonitrile (1.62 g, 0.008 mol), potassium hydroxide (2.29 g, 0.039 mol), ethane-1,2-diol (28 cm3) and water (2.3 cm3) was refluxed at 140° C. for 18 hr. The cooled mixture was poured into water and extracted with diethyl ether. The aqueous solution was acidified with hydrochloric acid and the mixture was extracted with diethyl ether. The ether extract was washed with water, dried (Na2SO4), filtered and the solvent was removed to give α-isopropylbenzofuran-6-acetic acid (0.90 g, 0.0041 mol, 50.8%). Recrystallised from petroleum ether (b.p. 60°-80° C.) m.p. 99°-100° C. (Found: C, 71.52; H, 6.65; C13H14O3 requires C, 71.54; H, 6.47%), t.l.c./silica/ethyl acetate RF 0.40.

후처리

  1. extractionextracted with diethyl ether
  2. extractionthe mixture was extracted with diethyl ether
  3. extractionThe ether extract
  4. washwas washed with water
  5. dry with materialdried (Na2SO4)
  6. filtrationfiltered
  7. customthe solvent was removed

출처 및 근거

ORD 기록
ord-4c00e3c704d840b78106dd02db71ab06
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04372970

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