Acetone → HCID 178473693, 화합물

HRID 1758303노트

반응식

HRID 1758303 반응식
[SH:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH3:13][C:14]([CH3:16])=[O:15]>>[C:14]([CH2:16][S:1][C:2]1[NH:6][N:5]=[N:4][N:3]=1)(=[O:15])[CH3:13]

참가 물질

4

반응물 3

HCID 180AcetoneHCID 11430Potassium CarbonateHCID 178527994HCID 178527994, 화합물

생성물 1

HCID 178473693HCID 178473693, 화합물

실험 절차

5-Mercapto-1,2,3,4-tetrazole (1 g), potassium carbonate (2 g) and β-chloroacetone (1.4 g) are added to acetone (50 ml) and the solution is refluxed with stirring for 2 hours. The reaction mixture is concentrated to dryness under reduced pressure and the residue is dissolved in chloroform. Insolubles are filtered off and the filtrate is concentrated under reduced pressure. The residue is purified by silica gel column chromatography (Kieselgel 60, eluant: benzene-ether (10:1) to obtain 5-acetylmethylthio-1,2,3,4-tetrazole (0.4 g) as colorless liquid.

후처리

  1. temperaturethe solution is refluxed
  2. concentrationThe reaction mixture is concentrated to dryness under reduced pressure
  3. dissolutionthe residue is dissolved in chloroform
  4. filtrationInsolubles are filtered off
  5. concentrationthe filtrate is concentrated under reduced pressure
  6. customThe residue is purified by silica gel column chromatography (Kieselgel 60, eluant

출처 및 근거

ORD 기록
ord-c7e52f44d55c4e29bfb4f06df1b9487d
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04372953

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