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Ethyl isocyanate → 6-[[(Ethylamino)carbonyl]amino]-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid

HRID 1758485
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인쇄 미리보기

반응식

HRID 1758485 반응식
[NH2:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[C:6]([C:13]([OH:15])=[O:14])=[CH:5]2.[CH2:16]([N:18]=[C:19]=[O:20])[CH3:17].C(N(CC)CC)C>CN(C)C=O>[CH2:16]([NH:18][C:19]([NH:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[NH:8][C:7](=[O:12])[C:6]([C:13]([OH:15])=[O:14])=[CH:5]2)=[O:20])[CH3:17]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 8022Ethyl isocyanateHCID 8471TriethylamineHCID 131063306-Amino-2-oxo-1,2-dihydroquinoline-3-carboxylic acid

생성물 1

HCID 205093946-[[(Ethylamino)carbonyl]amino]-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid수율 93%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 4.08 g (20 mmol) of 6-amino-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid, 2.37 ml (30 mmol) of ethyl isocyanate, 2.8 ml (20 mmol) of triethylamine and 50 ml of dimethylformamide is stirred with ice bath cooling for 4.5 hrs. The reaction solution is evaporated to dryness and is treated with 1 N hydrochloric acid and ethanol to yield 5.12 g of 6-[[(ethylamino)carbonyl]amino]-1,2-dihydro-2-oxo-3-quinolinecarboxylic acid.

후처리

  1. temperaturecooling for 4.5 hrs
  2. customThe reaction solution is evaporated to dryness
  3. additionis treated with 1 N hydrochloric acid and ethanol

출처 및 근거

ORD 기록
ord-ba06a6fcf0a248d09451586b186ec9ee
출처 데이터셋
uspto-grants-1983_02
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04374138

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