Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl isocyanate → 6-[[(Ethylamino)carbonyl]-amino]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl isocyanate | HCID 8022 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 6-Amino-4-hydroxyquinoline-3-carboxylic acid | HCID 3281201 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 6-[[(Ethylamino)carbonyl]-amino]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid | HCID 13106337 | — |
반응 단계
A mixture of 4.08 g (20 mmol) of 6-amino-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid [J. Pharm. Sci., 11, 1051 (1963)] 2.37 ml (30 mmol) of ethyl isocyanate, 2.8 ml (20 mmol) of triethylamine and 50 ml of dimethylformamide is stirred at room temperature overnight. The solution is evaporated to dryness and the residue is treated with 1 N hydrochloric acid. The solid is filtered to give 4.56 g of 6-[[(ethylamino)carbonyl]-amino]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid, mp>320° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US04374138 |
| 출처 데이터셋 | uspto-grants-1983_02 |
| ORD ID | ord-19a0b53de0654a1690ffa7d0681a309a |
| 출처 메모 | uspto-grants-1983_02 |