5-Aminoimidazole-4-carboxamide hydrochloride → 4-(2-Thienyl)imidazo[1,5-a]pyrimidine-8-carboxamide

HRID 1758794

반응식

HRID 1758794 반응식
C[N:2]([CH3:12])[CH:3]=[CH:4][C:5]([C:7]1[S:8][CH:9]=[CH:10][CH:11]=1)=O.Cl.NC1[N:16]=[CH:17][NH:18][C:19]=1[C:20]([NH2:22])=[O:21].C([O-])(=O)C.[Na+]>C(O)(=O)C>[S:8]1[CH:9]=[CH:10][CH:11]=[C:7]1[C:5]1[N:16]2[CH:17]=[N:18][C:19]([C:20]([NH2:22])=[O:21])=[C:12]2[N:2]=[CH:3][CH:4]=1

참가 물질

5

반응물 3

HCID 661465-Aminoimidazole-4-carboxamide hydrochlorideHCID 517045Sodium AcetateHCID 6023993-(Dimethylamino)-1-(2-thienyl)-2-propen-1-one

생성물 1

HCID 205089574-(2-Thienyl)imidazo[1,5-a]pyrimidine-8-carboxamide

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 0.01 mol of 3-dimethylamino-1-(2-thienyl)-2-propen-1-one (prepared as described in Example 1, Part A), 0.01 mol of 4amino-5-imidazolecarboxamide hydrochloride and 0.01 mol of anhydrous sodium acetate in 25 ml. of glacial acetic acid can be refluxed for 16 hours. The reaction mixture can be cooled and the crystalline precipitate collected by filtration and washed with water to produce 4-(2-thienyl)imidazo[1,5-a]pyrimidine-8-carboxamide.

후처리

  1. customprepared
  2. temperatureThe reaction mixture can be cooled
  3. filtrationthe crystalline precipitate collected by filtration
  4. washwashed with water

출처 및 근거

ORD 기록
ord-aead6c4625aa4cd5aa47356fb23eea00
출처 데이터셋
uspto-grants-1983_02
특허 번호
US04374988

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