4-(2-Amino-1-hydroxyethyl)-2-(hydroxymethyl)phenol → HCID 53825218, 화합물

HRID 1758977노트

반응식

HRID 1758977 반응식
[C:1]([CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH2:13][C:14](=O)[CH3:15])[CH:10]=[CH:11][CH:12]=1)([O:3][CH3:4])=[O:2].[OH:17][CH:18]([C:21]1[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([CH2:28][OH:29])[CH:22]=1)[CH2:19][NH2:20]>>[C:1]([CH2:5][O:6][C:7]1[CH:8]=[C:9]([CH2:13][CH:14]([NH:20][CH2:19][CH:18]([OH:17])[C:21]2[CH:26]=[CH:25][C:24]([OH:27])=[C:23]([CH2:28][OH:29])[CH:22]=2)[CH3:15])[CH:10]=[CH:11][CH:12]=1)([O:3][CH3:4])=[O:2]

참가 물질

3

반응물 2

HCID 129448344-(2-Amino-1-hydroxyethyl)-2-(hydroxymethyl)phenolHCID 20533273Methyl [3-(2-oxopropyl)phenoxy]acetate

생성물 1

HCID 53825218HCID 53825218, 화합물

실험 절차

The compound was prepared as in Example 1 from 1-(3-carbomethoxymethoxyphenyl) propan-2-one (1.82 g) and 2-hydroxy-2-(4-hydroxy-3-hydroxymethylphenyl) ethanamine (1.5 g) and crystallised from benzene m.p. 60°-64° as a 42:58 mixture of diastereoisomers.

후처리

  1. customcrystallised from benzene m.p. 60°-64° as a 42:58 mixture of diastereoisomers

출처 및 근거

ORD 기록
ord-5fca427d3d024d5684e79b661c0e9ec3
출처 데이터셋
uspto-grants-1982_07
특허 번호
US04338333

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