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Diethyl Ether → Ethyl 4,4-diethoxy-3-oxo-2-[(thiophen-2-yl)methylidene]butanoate

HRID 1759049
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인쇄 미리보기

반응식

HRID 1759049 반응식
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.[CH2:8]([O:10][CH:11]([O:20][CH2:21][CH3:22])[C:12](=[O:19])[CH2:13][C:14]([O:16][CH2:17][CH3:18])=[O:15])[CH3:9].C(OCC)C>N1CCCCC1.C1C=CC=CC=1>[C:2]1([CH:6]=[C:13]([C:12]([CH:11]([O:10][CH2:8][CH3:9])[O:20][CH2:21][CH3:22])=[O:19])[C:14]([O:16][CH2:17][CH3:18])=[O:15])[S:1][CH:5]=[CH:4][CH:3]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

6

반응물 3

HCID 3283Diethyl EtherHCID 73642-ThiophenecarboxaldehydeHCID 11138577Ethyl 4,4-diethoxy-3-oxobutanoate

생성물 1

HCID 54013227Ethyl 4,4-diethoxy-3-oxo-2-[(thiophen-2-yl)methylidene]butanoate

시약·촉매·용매 2

HCID 8082Piperidine촉매HCID 241Benzene용매

실험 절차

A solution of thiophene-2-carbaldehyde (2.2430 g), ethyl 4,4-diethoxyacetoacetate (4.3648 g) and piperidine (4 drops) in benzene (20 ml) was refluxed under azeotropic dehydration for 4.5 hours. After cooling, to the resultant solution was added diethyl ether, and the solution was washed with water and dried. The solvent was removed from the reaction mixture to give oily ethyl 2-(2-thenylidene)-4,4-diethoxyacetoacetate.

후처리

  1. washthe solution was washed with water
  2. customdried
  3. customThe solvent was removed from the reaction mixture

출처 및 근거

ORD 기록
ord-54ee4ba96ae448c887503aff192dcaee
출처 데이터셋
uspto-grants-1982_07
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US04338322

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