2-Bromobenzyl alcohol → Tert-butyl 3-hydroxy-3-[2-(hydroxymethyl)phenyl]piperidine-1-carboxylate

반응식

[Br:1][c:2]1[c:3]([CH2:8][OH:9])[cH:4][cH:5][cH:6][cH:7]1.[CH2:24]([Li:25])[CH2:26][CH2:27][CH3:28].[O:10]=[C:11]1[CH2:12][N:13]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:14][CH2:15][CH2:16]1>>[c:2]1([C:11]2([OH:10])[CH2:12][N:13]([C:17](=[O:18])[O:19][C:20]([CH3:21])([CH3:22])[CH3:23])[CH2:14][CH2:15][CH2:16]2)[c:3]([CH2:8][OH:9])[cH:4][cH:5][cH:6][cH:7]1

참가 물질

반응물 3

HCID 728502-Bromobenzyl alcohol

HCID 2756825Tert-butyl 3-oxopiperidine-1-carboxylate

HCID 178418339Butyllithium

생성물 1

HCID 68557078Tert-butyl 3-hydroxy-3-[2-(hydroxymethyl)phenyl]piperidine-1-carboxylate

출처 및 근거

ORD 기록: ord-f1c15cca726249299301ce0276d07190
출처 데이터셋: Training data from https://doi.org/10.1039/C8SC04228D (6/10)
DOI: 10.1039/C8SC04228D

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