1,2-Ethanediamine, N1,N2-bis(phenylmethyl)-, acetate (1:2) → Benzathine

HRID 1759306

반응식

HRID 1759306 반응식
C(O)(=O)C.C(O)(=O)C.[CH2:9]([NH:16][CH2:17][CH2:18][NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1>O>[CH2:9]([NH:16][CH2:17][CH2:18][NH:19][CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1

참가 물질

3

반응물 1

HCID 312281,2-Ethanediamine, N1,N2-bis(phenylmethyl)-, acetate (1:2)

생성물 1

HCID 8793Benzathine

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

306 mg. (0.001 ml) of BL-P2013 was dissolved in 7 ml. H2O and added to a solution of 180 mg. (0.0005 mol) of N,N'-dibenzylethylenediamine diacetate in 7 ml. H2O. The mixture was stirred and the salt crystallized and after stirring approximately 10-15 minutes the salt was collected by filtration and air dried to yield N,N'-dibenzylethylenediamine salt of BL-P2013 (300 mg). The material was recrystallized by dissolving it in approximately 10 ml. of boiling acetone and diluting with ether to the cloud point. 260 mg. of air dried and vacuum dried material was obtained.

후처리

  1. customthe salt crystallized
  2. stirringafter stirring approximately 10-15 minutes the salt
  3. filtrationwas collected by filtration and air
  4. customdried

출처 및 근거

ORD 기록
ord-12990cf6932a4d5693e1350d9ae2d641
출처 데이터셋
uspto-grants-1982_07
특허 번호
US04340539

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