Formaldehyde → HCID 20531688, 화합물

HRID 1759319노트

반응식

HRID 1759319 반응식
[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][NH:6][CH2:7][CH:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH3:19])[CH:11]=1)[OH:9].[CH2:24]=O>C(O)=O>[CH3:1][O:2][C:3]1[CH:23]=[CH:22][CH:21]=[CH:20][C:4]=1[CH2:5][N:6]([CH3:24])[CH2:7][CH:8]([C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([O:18][CH3:19])[CH:11]=1)[OH:9]

참가 물질

4

반응물 2

HCID 712FormaldehydeHCID 20531701HCID 20531701, 화합물

생성물 1

HCID 20531688HCID 20531688, 화합물수율 93%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

A mixture of 1.85 g. (0.0058 m) of N-(2-methoxybenzyl)-1-(3,4-dimethoxyphenyl)-2-aminoethanol prepared as in Example 3, 4.8 ml of 90% formic acid and 4.5 ml of 37% formaldehyde was heated in a steam bath for 18 hours. The aqueous portion was evaporated and the residue redissolved in water. After making the solution acid with concentrated hydrochloroic acid, the mixture was heated for 20 minutes, cooled, made basic and extracted with chloroform. The organic extract was washed with water, brine then dried. Evaporation gave 1.8 g (93%) of N-(2-methoxybenzyl)-1-(3,4-dimethoxyphenyl)-N-methyl-2-amino ethanol as an oil.

후처리

  1. additionA mixture of 1.85 g
  2. temperaturewas heated in a steam bath for 18 hours
  3. customThe aqueous portion was evaporated
  4. dissolutionthe residue redissolved in water
  5. concentrationwith concentrated hydrochloroic acid
  6. temperaturethe mixture was heated for 20 minutes
  7. temperaturecooled
  8. extractionextracted with chloroform
  9. extractionThe organic extract
  10. washwas washed with water, brine
  11. customthen dried
  12. customEvaporation

출처 및 근거

ORD 기록
ord-17e0ed5a363248feaa1889abfa120db1
출처 데이터셋
uspto-grants-1982_07
특허 번호
US04340600

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