1,1-Diphenylacetone → 3-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide

HRID 1759374

반응식

HRID 1759374 반응식
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[C:8](=[O:10])[CH3:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:17]CC(=O)C(C1C=CC=CC=1)C1C=CC=CC=1.[CH3:34][C:35]1([CH3:42])[CH2:40][NH:39][C:38](=[S:41])[NH:37][CH2:36]1>CC(C)=O>[BrH:17].[C:11]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:8]2([OH:10])[N:39]3[CH2:40][C:35]([CH3:42])([CH3:34])[CH2:36][N:37]=[C:38]3[S:41][CH2:9]2)[CH:12]=[CH:13][CH:14]=[CH:15][CH:16]=1

참가 물질

5

반응물 3

HCID 699071,1-DiphenylacetoneHCID 27946353-Bromo-1,1-diphenylacetone2회HCID 38664875,5-Dimethyl-1,4,5,6-tetrahydro-pyrimidine-2-thiol

생성물 1

HCID 155712123-Diphenylmethyl-2,3,6,7-tetrahydro-6,6-dimethyl-5H-thiazolo[3,2-a]pyrimidin-3-ol hydrobromide

시약·촉매·용매 1

HCID 180Acetone용매2회

실험 절차

A 2.1 g. portion of 1,1-diphenyl-2-propanone is converted to 1-bromo-3,3-diphenyl-2-propanone as described in Example 22. This 1-bromo-3,3-diphenyl-2-propanone is dissolved in 15 ml. of acetone and added to a boiling mixture of 1.0 g. of tetrahydro-5,5-dimethyl-2(1H)-pyrimidinethione in 50 ml. of acetone. The mixture is allowed to stand at room temperature for 24 hours and the resulting solid is collected by filtration, giving the desired product, m.p. 259°-261° C.

후처리

  1. filtrationthe resulting solid is collected by filtration

출처 및 근거

ORD 기록
ord-74b9700bce794469a10ff051d82ec604
출처 데이터셋
uspto-grants-1982_07
특허 번호
US04340734

연결된 노트

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