Ammonium Chloride → 3-amino-4-chlorobenzophenone

HRID 1759386노트

반응식

HRID 1759386 반응식
[Cl-].[NH4+].[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:11])=[CH:6][C:5]=1[N+:18]([O-])=O>[Fe].CC1C=CC=CC=1>[NH2:18][C:5]1[CH:6]=[C:7]([C:10]([C:12]2[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=2)=[O:11])[CH:8]=[CH:9][C:4]=1[Cl:3]

참가 물질

5

반응물 2

HCID 25517Ammonium ChlorideHCID 417434-Chloro-3-nitrobenzophenone

생성물 1

HCID 107995483-amino-4-chlorobenzophenone

시약·촉매·용매 2

HCID 23925Iron촉매HCID 1140Toluene용매2회

실험 절차

To a stirred and refluxing mixture of 11.2 parts of iron, 100 parts of ammonium chloride solution 0.8 N and 20 parts of methylbenzene are added 10.5 parts of (4-chloro-3-nitrophenyl)phenylmethanone and the whole is further stirred at reflux temperature for one hour. Methylbenzene (80 parts) is added and the whole is filtered over Hyflo. The organic layer is separated, dried, filtered and evaporated. The residue is washed with cyclohexane, yielding 8.4 parts of (3-amino-4-chlorophenyl)phenylmethanone; mp. 91.9° C.

후처리

  1. temperaturerefluxing
  2. stirringthe whole is further stirred
  3. temperatureat reflux temperature for one hour
  4. filtrationthe whole is filtered over Hyflo
  5. customThe organic layer is separated
  6. customdried
  7. filtrationfiltered
  8. customevaporated
  9. washThe residue is washed with cyclohexane

출처 및 근거

ORD 기록
ord-9e37156dceda471ea11ca19b2137ca48
출처 데이터셋
uspto-grants-1982_07
특허 번호
US04340738

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