Water → 4-Hydroxyethyl-5-methyl-2-phenylimidazole

HRID 1760489노트

반응식

HRID 1760489 반응식
C([O:3][C:4]([CH2:6][C:7]1[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:10][C:11]=1[CH3:12])=O)C.[H-].[Al+3].[Li+].[H-].[H-].[H-].O>O1CCCC1>[OH:3][CH2:4][CH2:6][C:7]1[N:8]=[C:9]([C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[NH:10][C:11]=1[CH3:12]

참가 물질

5

반응물 3

HCID 962WaterHCID 21226445Aluminium lithium hydrideHCID 22597552Ethyl 5-methyl-2-phenylimidazole-4-acetate

생성물 1

HCID 543635624-Hydroxyethyl-5-methyl-2-phenylimidazole

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매3회

실험 절차

A solution of 4-ethoxycarbonylmethyl-5-methyl-2-phenylimidazole (19.7 g) in tetrahydrofuran (100 ml) was added dropwise (in 45 min) to lithium aluminium hydride (10 g) in tetrahydrofuran (150 ml). After 2 h refluxing the reaction mixture was allowed to stand overnight at r.t. It was cooled in an ice bath and water (40 ml) and tetrahydrofuran (50 ml) were added. The solids were filtered off and washed with diethylether.

후처리

  1. temperatureAfter 2 h refluxing the reaction mixture
  2. temperatureIt was cooled in an ice bath
  3. filtrationThe solids were filtered off
  4. washwashed with diethylether

출처 및 근거

ORD 기록
ord-8a360cf9f533446187ab97dca9eb016c
출처 데이터셋
uspto-grants-2005_01
특허 번호
US06841553B2

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