Chloroacetyl chloride → 2-Chloro-N-[4-(1-ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenoxy)-pyridin-3-yl]-acetamide

반응식

C(C([C:6]1[C:7]([NH2:24])=[C:8]([NH2:23])[C:9]([O:13][C:14]2[C:19]([CH3:20])=[CH:18][C:17]([CH3:21])=[CH:16][C:15]=2[CH3:22])=[N:10][C:11]=1[CH3:12])CC)C.[Cl:25][CH2:26][C:27](Cl)=[O:28].C(N([CH2:35][CH3:36])CC)C.[CH2:37]1[CH2:41]OC[CH2:38]1>>[Cl:25][CH2:26][C:27]([NH:23][C:8]1[C:9]([O:13][C:14]2[C:15]([CH3:22])=[CH:16][C:17]([CH3:21])=[CH:18][C:19]=2[CH3:20])=[N:10][C:11]([CH3:12])=[CH:6][C:7]=1[NH:24][CH:38]([CH2:35][CH3:36])[CH2:37][CH3:41])=[O:28]

참가 물질

반응물 4

HCID 6577Chloroacetyl chloride

HCID 8028Tetrahydrofuran

HCID 8471Triethylamine

HCID 867595891-Ethyl-propyl-6-methyl-2-(2,4,6-trimethyl-phenoxy)-pyridine-3,4-diamine

생성물 1

HCID 120183492-Chloro-N-[4-(1-ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenoxy)-pyridin-3-yl]-acetamide

실험 절차

To a solution of N+(1-ethyl-propyl-6-methyl-2-(2,4,6-trimethyl-phenoxy)-pyridine-3,4-diamine (250 mg, 0.763 mmol) in dry THF was added chloroacetyl chloride (86 mg, 0.763 mmol) and triethylamine (77 mg, 0.763 mmol) at 0° C. The resulting mixture was warmed to room temperature and stirred for 1 hr. The mixture was quenched with water and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated to dryness to give the title compound as a solid. The solid was purified through silica gel column chromatography to give 280 mg(91%) of tan crystals, mp. 152-154° C.