3-(Dimethylamino)-2,2-dimethyl-1-propanol → HCID 22594117, 화합물

HRID 1760981

반응식

HRID 1760981 반응식
Cl[C:2]1[N:7]=[C:6]([NH:8][C:9]2[CH:14]=[C:13]([NH:15][C:16]([C:18]3[C:23]4[O:24][C:25]5[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=5[C:22]=4[CH:21]=[CH:20][CH:19]=3)=[O:17])[CH:12]=[CH:11][C:10]=2[CH3:31])[CH:5]=[CH:4][N:3]=1.[CH3:32][N:33]([CH3:40])[CH2:34][C:35]([CH3:39])([CH3:38])[CH2:36][OH:37]>>[CH:21]1[C:22]2[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[O:24][C:23]=2[C:18]([C:16]([NH:15][C:13]2[CH:12]=[CH:11][C:10]([CH3:31])=[C:9]([CH:14]=2)[NH:8][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([O:37][CH2:36][C:35]([CH3:39])([CH3:38])[CH2:34][N:33]([CH3:40])[CH3:32])[N:7]=2)=[O:17])=[CH:19][CH:20]=1

참가 물질

3

반응물 2

HCID 879193-(Dimethylamino)-2,2-dimethyl-1-propanolHCID 22594095HCID 22594095, 화합물

생성물 1

HCID 22594117HCID 22594117, 화합물

실험 절차

Using an analogous procedure to that described in Example 8, 2-chloro-4-[5-(4-dibenzofuranylcarbonylamino)-2-methylanilino]pyrimidine was reacted with 3-dimethylamino-2,2-dimethylpropanol. The reaction mixture was evaporated and the residue was purified by column chromatography on silica using increasingly polar mixtures of methylene chloride and methanol as eluent followed by increasingly polar mixtures of methylene chloride and methanol containing 1% aqueous ammonium hydroxide solution. There was thus obtained the title compound; NMR Spectrum: (DMSOd6) 0.85 (s, 6H), 2.14 (s, 6H), 2.18 (s, 2H), 3.94 (s, 2H), 6.22 (d, 1H), 7.23 (d, 1H), 7.4-7.58 (m, 4H), 7.78 (d, 1H), 7.84 (d, 1H), 7.96 (m, 2H), 8.2 (d, 1H), 8.31 (d, 1H); Mass Spectrum: M+H+ 524.

후처리

  1. customThe reaction mixture was evaporated
  2. customthe residue was purified by column chromatography on silica using
  3. temperatureincreasingly polar mixtures of methylene chloride and methanol as eluent
  4. temperatureby increasingly polar mixtures of methylene chloride and methanol containing 1% aqueous ammonium hydroxide solution

출처 및 근거

ORD 기록
ord-3fae238040344cc0998edd6d90fabd81
출처 데이터셋
uspto-grants-2005_01
특허 번호
US06846827B1

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