Potassium Carbonate → 1h-Isoindol-1-one,6-[(3-fluorophenyl)methoxy]-2,3-dihydro-

HRID 1761024노트

반응식

HRID 1761024 반응식
[OH:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][NH:7][C:8]2=[O:11])=[CH:4][CH:3]=1.[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16]Br.C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:12][C:13]1[CH:14]=[C:15]([CH:18]=[CH:19][CH:20]=1)[CH2:16][O:1][C:2]1[CH:10]=[C:9]2[C:5]([CH2:6][NH:7][C:8]2=[O:11])=[CH:4][CH:3]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 680073-Fluorobenzyl bromideHCID 115283646-Hydroxy-2,3-dihydro-1H-isoindol-1-one

생성물 1

HCID 117086731h-Isoindol-1-one,6-[(3-fluorophenyl)methoxy]-2,3-dihydro-수율 83.3%

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

A mixture of 6-hydroxy-2,3-dihydro-isoindol-1-one (125.0 mg, 0.84 mmol) and 3-fluorobenzylbromide (174.3 mg, 0.92 mmol) in acetone (5 mL) containing potassium carbonate (276.4 mg, 2.0 mmol) was heated under reflux for 17 h. After cooling to RT the mixture was filtered and evaporated. The residue was purified by chromatography (SiO2, CH2Cl2:2N NH3-MeOH 90:10) to afford the title product (180 mg, 83%) as a white solid. MS m/e=258.2 (M+H+).

후처리

  1. temperaturewas heated
  2. temperatureunder reflux for 17 h
  3. filtrationwas filtered
  4. customevaporated
  5. customThe residue was purified by chromatography (SiO2, CH2Cl2:2N NH3-MeOH 90:10)

출처 및 근거

ORD 기록
ord-d6837fb75304433bbf474a8ca731aa9d
출처 데이터셋
uspto-grants-2005_01
특허 번호
US06846832B2

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