Tetramethoxypropane → 2-Amino-4-chloro-pyrido[2,3-d]pyrimidine

반응식

[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[C:4]([NH2:9])[N:3]=1.CO[CH:12](OC)[CH2:13][CH:14](OC)OC>>[NH2:1][C:2]1[N:7]=[C:6]([Cl:8])[C:5]2[CH:14]=[CH:13][CH:12]=[N:9][C:4]=2[N:3]=1

참가 물질

반응물 2

HCID 66019Tetramethoxypropane

HCID 674322,4-Diamino-6-chloropyrimidine

생성물 1

HCID 200439332-Amino-4-chloro-pyrido[2,3-d]pyrimidine

실험 절차

Starting from 2,6-diamino-4-chloropyrimidine and 1,1,3,3-tetramethoxypropane and using a procedure analogous to that of Example 71, the above compound is isolated after chromatographic purification on silica gel with methanol/diisopropylether (1:1) as a yellow oil which can be used in the following reactions without any further purification.

후처리

customthe above compound is isolated
customafter chromatographic purification on silica gel with methanol/diisopropylether (1:1) as a yellow oil which
customcan be used in the following reactions without any further purification

출처 및 근거

ORD 기록: ord-64b68a6731894e339d2dfaf406409927
출처 데이터셋: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04826528

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