Acetic Acid → 110714-14-2

반응식

[N:1]1([C:6]2[N:11]=[N:10][C:9](Cl)=[CH:8][CH:7]=2)[CH:5]=[CH:4][N:3]=[CH:2]1.C(O)(=[O:15])C>>[N:1]1([C:6]2[CH:7]=[CH:8][C:9](=[O:15])[NH:10][N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

반응물 2

HCID 176Acetic Acid

HCID 27709033-Chloro-6-(1H-imidazol-1-yl)pyridazine

생성물 1

HCID 14551076110714-14-2수율 55%

실험 절차

9.93 g (0.055 mole) of 6-(1-imidazolyl)-3-chloropyridazine [prepared according to J. Med. Chem. 24, 59 (1981)] are boiled with 7.7 g (0.0781 mole) of fused potassium acetate in 114 ml of acetic acid under reflux for 10 hours and then evaporated to dryness under reduced pressure. The residue is taken up in 200 ml of chloroform, the precipitate is filtered off, washed 4 times with water, then with ether and diisopropyl ether and dried to give 4.9 g (55% yield) of the aimed product, m. p. 239°-240° C.

후처리

temperatureunder reflux for 10 hours
customevaporated to dryness under reduced pressure
filtrationthe precipitate is filtered off
washwashed 4 times with water
dry with materialwith ether and diisopropyl ether and dried

출처 및 근거

ORD 기록: ord-63859f0fee8a463687f86b608effa81c
출처 데이터셋: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04826845

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